A lumped-parameter model of flow through the mitral valve was developed. The model can use minimally-invasive Doppler ultrasound velocity waveforms as model inputs. The model is based on a previously developed model that was developed and calibrated in porcine trials. We have continued the validation of the model in canine trials with the long term goal of developing a clinically useful diagnostic tool in humans. This velocity driven model is a key step toward development of that tool.